Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K

Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam, and lorazepam) in ethanol + water mixtures at 303.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained version of the Jouyban−Acree model and...