Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
Abstract
Transcription factors and chromatin modifiers are important in the programming and reprogramming of cellular states during development. Transcription factors bind to enhancer elements and recruit coactivators and chromatin-modifying enzymes to facilitate transcription initiation. During differentiation a subset of these enhancers must be silenced, but the mechanisms underlying enhancer silencing are poorly understood. Here we show that the...
Paper Details
Title
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
Published Date
Feb 1, 2012
Journal
Volume
482
Issue
7384
Pages
221 - 225
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Notes
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