Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome

Ca + mishandling due to impaired activity of cardiac sarco(endo)plasmic reticulum Ca 2+ ATPase (SERCA2a) has been associated with the development of left ventricular diastolic dysfunction in insulin-resistant cardiomyopathy. However, the molecular causes underlying SERCA2a alterations induced by insulin resistance and related metabolic disorders, such as metabolic syndrome (MetS), are not completely understood. In this study, we used a...