Match!

Porous silicon biosensor: current status.

Published on Mar 1, 2013in Biosensors and Bioelectronics9.518
· DOI :10.1016/j.bios.2012.09.045
Saakshi Dhanekar8
Estimated H-index: 8
(Jamia Millia Islamia),
Swati Jain3
Estimated H-index: 3
(IITD: Indian Institute of Technology Delhi)
Abstract
Abstract Biosensing technologies cater to modern day diagnostics and point of care multi-specialty clinics, hospitals and laboratories. Biosensors aggregate the sensitivity of detection methodologies and constitutional selectivity of biomolecules. Endeavors to develop highly sensitive, fast, stable and low cost biosensors have been made possible by extensive and arduous research. Immense research work is going on for detection of molecules using various materials as immobilization substrate and sensing elements. Amongst materials being used as bio-sensing substrates, nano-porous silicon (PS) has amassed attention and gained popularity in recent years. It has captivating and tunable features like ease of fabrication, special optico-physico properties, tailored morphological structure and versatile surface chemistry enhancing its prospects as transducer for fabricating biosensors. The present review describes the fabrication of PS and its biosensing capabilities for detection of various analytes including, but not limited to, glucose, DNA, antibodies, bacteria and viruses. Attention has been consecrated on the various methodologies such as electrical, electrochemical, optical and label free techniques along with the performances of these biosensors. It concludes with some future prospects and challenges of PS based biosensors.
  • References (68)
  • Citations (102)
References68
Newest
#1Saakshi Dhanekar (Jamia Millia Islamia)H-Index: 8
#2Shofiqul Islam (Jamia Millia Islamia)H-Index: 14
Last. Harsh (Solid State Physics Laboratory)H-Index: 1
view all 3 authors...
Surface stability is achieved and demonstrated by porous silicon (PS) fabricated using a wavelength-dependent photo-electrochemical (PEC) anodization technique. During anodization, the photon flux for all wavelengths was kept constant while only the effect of light wavelength on the surface morphology of PS was investigated. PS optical sensors were realized, characterized and tested using a photoluminescence (PL) quenching technique. An aliphatic chain of alcohols (methanol to n-octanol) was det...
13 CitationsSource
#2Vinita KumariH-Index: 2
Last. Shofiqul IslamH-Index: 14
view all 3 authors...
7 CitationsSource
#1Michael J. SailorH-Index: 73
Preface FUNDAMENTALS OF POROUS SILICON PREPARATION Introduction Chemical Reactions Governing the Dissolution of Silicon Experimental Set-up and Terminology for Electrochemical Etching of Porous Silicon Electrochemical Reactions in the Silicon System Density, Porosity, and Pore Size Definitions Mechanisms of Electrochemical Dissolution and Pore Formation Resume of the Properties of Crystalline Silicon Choosing, Characterizing, and Preparing a Silicon Wafer PREPARATION OF MICRO-, MESO-, AND MACRO-...
125 Citations
#1Abhishek Singh (NCSU: North Carolina State University)H-Index: 10
#2Hamed Eksiri (NCSU: North Carolina State University)H-Index: 1
Last. Yaroslava G. Yingling (NCSU: North Carolina State University)H-Index: 21
view all 3 authors...
The molecular recognition properties of DNA gave rise to many novel materials and applications such as DNA biosensors, DNA-functionalized colloidal materials, DNA origami and DNA-based directed surface assembly. The DNA-functionalized surfaces are used in biosensors and for programmed self-assembly of biological, organic and inorganic moieties into novel materials. However, surface density, length, and linker design of the surface functionalized DNAs significantly influence the properties of DNA...
8 CitationsSource
#1Huihua Liu (Curtin University)H-Index: 7
#2Deeptangshu Chaudhary (Curtin University)H-Index: 17
Last. Moses O. Tadé (Curtin University)H-Index: 57
view all 4 authors...
We studied a hydrophilic, plasticized bionanocomposite system involving sorbitol plasticizer, amylose biopolymer, and montmorillonite (MMT) for the presence of competitive interactions among them at different moisture content. Synchrotron analysis via small angle X-ray scattering (SAXS) and thermal analysis using differential scanning calorimetry (DSC) were performed to understand crystalline growth and the distribution of crystalline domains within the samples. The SAXS diffraction patterns sho...
16 CitationsSource
#1Saakshi Dhanekar (Jamia Millia Islamia)H-Index: 8
#2Shofiqul Islam (Jamia Millia Islamia)H-Index: 14
Last. Harsh (DRDO: Defence Research and Development Organisation)H-Index: 3
view all 4 authors...
Crucial sensor parameters like sensitivity, response time and recovery time at low ppm were studied and analysed by photoluminescence (PL) quenching technique. A comparison was drawn from various porous silicon samples prepared under different electrochemical anodization conditions. Porosity dependent sensing results were analysed and it was observed that samples turned more sensitive with an increase in porosity. Samples were tested in the presence of linear aliphatic alcohols (methanol to n-oc...
5 CitationsSource
#1Pier Andrea SerraH-Index: 1
9 CitationsSource
17 CitationsSource
#1Date Abhijit AH-Index: 1
#2Vador NimishH-Index: 1
Last. Nagarsenker Mangal SH-Index: 1
view all 4 authors...
262 Citations
#1Simone Ciampi (UNSW: University of New South Wales)H-Index: 24
#2Jason B. Harper (UNSW: University of New South Wales)H-Index: 27
Last. J. Justin Gooding (UNSW: University of New South Wales)H-Index: 63
view all 3 authors...
Organic functionalization of non-oxidized silicon surfaces, while allowing for robust chemical passivation of the inorganic substrate, is intended and expected to broaden the chemical, physical and electronic properties of the currently most relevant technological material. Numerous protocols are now available for the preparation of Si–C, Si–O and Si–N bound layers. In particular, the covalent attachment of 1-alkenes and 1-alkynes onto hydride-terminated Si(100) and Si(111) has seen a wealth of ...
209 CitationsSource
Cited By102
Newest
#1Eric Luis (NTU: Nanyang Technological University)
#2Houwen Matthew Pan (NTU: Nanyang Technological University)H-Index: 1
Last. Wai Yee Yeong (NTU: Nanyang Technological University)H-Index: 28
view all 6 authors...
The first successful direct 3D printing, or additive manufacturing (AM), of heat-cured silicone meniscal implants, using biocompatible and bio-implantable silicone resins is reported. Silicone implants have conventionally been manufactured by indirect silicone casting and molding methods which are expensive and time-consuming. A novel custom-made heat-curing extrusion-based silicone 3D printer which is capable of directly 3D printing medical silicone implants is introduced. The rheological study...
Source
#1Valentina Pukhova (University of Milan)H-Index: 3
view all 5 authors...
The porous silicon (por-Si) has many applications in various scientific fields and research tasks, and there is a particular interest in application of por-Si as a biomaterial. The purpose of our work is to investigate the possibility of creating biomaterials for osteoplastics based on nanocomposites of silica with hydroxyapatite (HAP) that is a mineral phase of bones. It is very important to control silicon layer parameters, since parameters of formed silicon layer are very important for such a...
Source
#1N. L. Grevtsov (BSUIR: Belarusian State University of Informatics and Radioelectronics)
Last. V. P. Bondarenko (BSUIR: Belarusian State University of Informatics and Radioelectronics)
view all 4 authors...
The influence of silicon wafer crystallographic orientation on the formation of porous silicon during anodization in an HF solution is studied. Cross-section SEM image comparison of samples with different crystallographic orientations has shown that (111) Si samples exhibit a more branching, tree-like pore structure with a higher porosity value compared to (100) Si samples. This phenomenon is explained by pointing out differences in crystal structure and numbers of Si-Si chemical bonds in differ...
Source
Abstract The natural biodegradabilty of porous silicon (pSi) in physiological media limits its wider usage for implantable systems. We report the stabilization of porous silicon (pSi) membranes by chemical surface oxidation using RCA1 and RCA2 protocols, which was followed by a PEGylation process using a silane-PEG. These surface modifications stabilized the pSi to allow a long period of immersion in PBS, while leaving the pSi surface sufficiently hydrophilic for good filtration and diffusion of...
1 CitationsSource
#1Yi Pei (UNSW: University of New South Wales)
#2Thomas G. Molley (UNSW: University of New South Wales)
Last. Kristopher A. Kilian (UNSW: University of New South Wales)H-Index: 28
view all 3 authors...
Structured color in nature is controlled by nano giving rise to a photonic bandgap. This study presents a biomimetic optical material based on polymeric inverse opals that respond to enzyme activity. Polymer colloids provide a template in which acryloyl-functionalized poly(ethylene glycol) is integrated; dissolution of the colloids leads to a hydrogel inverse opal that can be lithographically patterned using transfer printing. Incorporating enzyme substrates within the voids provides a material ...
Source
#1M.H. Beigi (Royan Institute)H-Index: 1
#2Naghmeh SafaieH-Index: 1
Last. Amirkianoosh KianiH-Index: 7
view all 4 authors...
In this study, we describe the formation method of web-like three-dimensional (3-D) titania nanofibrous structures coated on transparent substrate via a high intensity laser induced reverse transfer (HILIRT) process. First, we demonstrate the mechanism of ablation and deposition of Ti on the glass substrates using multiple picosecond laser pulses at ambient air in an explicit analytical form and compare the theoretical results with the experimental results of generated nanofibers. We then examin...
Source
#1Farzad Allahnouri (Urmia University)H-Index: 1
#2Khalil Farhadi (Urmia University)H-Index: 25
Last. Rahim Molaei (Urmia University)H-Index: 8
view all 4 authors...
The work describes an electrochemical sensor for the determination of the tranquilizer clonazepam (CZP) in serum and pharmaceutical preparations. A screen printed carbon electrode (SPCE) was modified with copper nanoparticles anchored on porous silicon (PSi). The surface of the SPCEs modified with the Cu/PSi nanostructure was characterized by X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoemission spectroscopy, energy dispersive X-ray spectroscopy and field-emission scann...
Source
#1G. K. Mussabek (KazGU: Al-Farabi University)
#2D. Yermukhamed (KazGU: Al-Farabi University)H-Index: 1
Last. V.Y. Timoshenko (National Research Nuclear University MEPhI)H-Index: 27
view all 7 authors...
A significant change in effective reflectance spectra of nanostructured porous silicon layers grown with different times of metal-assisted chemical etching is detected. The low reflectances at the level of 5–10% measured in the spectral range of 200–400 nm are explained by strong elastic scattering of light in combination with absorption in silicon nanostructures, while a reflectance increase in the range of 500–1800 nm, which is visually detected as a “white” layer appearance is associated with...
Source
#1Naghmeh SafaieH-Index: 1
Last. Amirkianoosh KianiH-Index: 7
view all 3 authors...
Bioactive glass is used extensively in biomedical applications due to its quality and effectiveness in tissue regeneration. Bioactive glasses are able to interact with biological systems and can be used in humans to improve tissue regeneration without any side effects. Bioactive glass is a category of glasses that maintain good contact with body organs and remain biocompatible for a long time after implementation. They have the potential to form a hydroxyapatite surface as a biocompatible layer ...
1 CitationsSource
Source