Interaction And Unfolding Of A Model Exchangeable Apolipoprotein, ApolpIII, At Lipid Model Membranes

Transport of fat in the bloodstream is mediated by lipoprotein particles. These hydrophobic particles are covered by a (phospho-)lipid monolayer and further stabilized by exchangeable apolipoproteins. Their amphipatic helix bundle is thought to unfold upon interaction with the (phospho)lipid monolayer. The dynamics of this interaction at lipid interfaces has not been directly shown experimentally. Here we report on the structure of monolayers...