Dexamethasone-induced Hypertrophy in Rat Neonatal Cardiac Myocytes Involves an Elevated L-type Ca2+Current

The mechanism responsible for dexamethasone-induced hypertrophy in infants has not been defined. In this study, we have investigated the role of-type Ca2+currents in the development of dexamethasone-induced hypertrophy in rat neonatal cardiac myocytes. Using cytoplasmic membrane capacitance measurements, we have shown that the size of the cells treated with dexamethasone were larger than those of the control cells. In addition, treating the...