Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside
Abstract
We report the application of our phosphoramidate ProTide technology to the ribonucleoside analogue 4‘-azidouridine to generate novel antiviral agents for the inhibition of hepatitis C virus (HCV). 4‘-Azidouridine did not inhibit HCV, although 4‘-azidocytidine was a potent inhibitor of HCV replication under similar assay conditions. However 4‘-azidouridine triphosphate was a potent inhibitor of RNA synthesis by HCV polymerase, raising the...
Paper Details
Title
Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside
Published Date
Mar 17, 2007
Volume
50
Issue
8
Pages
1840 - 1849
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