Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.

Volume: 1849, Issue: 3, Pages: 328 - 341
Published: Mar 1, 2015
Abstract
The genes encoding luteinizing hormone and follicle stimulating hormone are activated by gonadotropin-releasing hormone (GnRH), and we hypothesized that this involves GnRH-induction of various histone modifications. At basal conditions in an immature gonadotrope-derived cell line, the hormone-specific β-subunit gene promoters are densely packed with histones, and contain low levels of H3K4 trimethylation (H3K4me3). GnRH both induces this...
Paper Details
Title
Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.
Published Date
Mar 1, 2015
Volume
1849
Issue
3
Pages
328 - 341
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