Novel internally quenched fluorogenic substrates for angiotensin I-converting enzyme and carboxypeptidase Y
Abstract
Angiotensin I-converting enzyme (ACE, EC 3.4.15.1) is one of the most important enzymes in the renin-angiotensin system, a major blood pressure control system in mammals. We synthesized novel internally quenched fluorogenic (IQF) substrates for ACE based on the cleavage site of an angiotensin I, introducing N-methyl anthranic acid (Nma) and N(ε)-2,4-dinitrophenyl-lysine (Lys(Dnp))at the N- and C-terminal regions. Kinetic parameters of the...
Paper Details
Title
Novel internally quenched fluorogenic substrates for angiotensin I-converting enzyme and carboxypeptidase Y
Published Date
Jan 1, 2011
Journal
Volume
32
Issue
6
Pages
407 - 411
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