Identification and Characterization of ALK Kinase Splicing Isoforms in Non–Small-Cell Lung Cancer
Abstract
Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset of non-small-cell lung cancer (NSCLC) and predict for response to the tyrosine kinase inhibitor crizotinib. In this study, we evaluated the yet unknown frequency and functional role of ALK splicing isoforms in NSCLC.We analyzed 270 cases of NSCLC for ALK kinase domain splicing aberrations and in addition generated constructs with full-length echinoderm...
Paper Details
Title
Identification and Characterization of ALK Kinase Splicing Isoforms in Non–Small-Cell Lung Cancer
Published Date
Feb 1, 2014
Journal
Volume
9
Issue
2
Pages
248 - 253
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