Charting a course for genomic medicine from base pairs to bedside

To mark the tenth anniversary of the publication reporting a draft sequence of the human genome by the Human Genome Project, this issue of Nature presents three major papers about human genomics. Eric Lander, present at the birth of the Human Genome Project, looks back at what has been achieved in genomics and speculates on future prospects. Elaine Mardis discusses the DNA sequencing technologies that have catalysed the rapid genomic advances...