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Contributions of total and regional fat mass to risk for cardiovascular disease in older women.
Published on May 1, 2002in American Journal of Physiology-endocrinology and Metabolism 4.02
· DOI :10.1152/ajpendo.00467.2001
R. E. Van Pelt5
Estimated H-index: 5
(Anschutz Medical Campus),
Ellen M. Evans33
Estimated H-index: 33
+ 2 AuthorsWendy M. Kohrt42
Estimated H-index: 42
(Anschutz Medical Campus)
The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1) area under the curve for the insulin (INSAUC) response to an oral glucose tolerance test (OGTT), 2) product of the OGTT glucose and insulin areas (INSAUC×GLUAUC), 3) serum triglycerides (TG), and 4) high-density lipoprotein (HDL)-cholesterol. Trunk fat mass was the strongest independent predictor of each of the primary dependent variables. In multivariate regression models, trunk fat mass was associated with unfavorable levels of INSAUC, INSAUC×GLUAUC, TG, and HDL-C, whereas leg fat mass was favorably associated with each of these variables. Thus trunk fat is a strong independent predictor of i...
  • References (38)
  • Cited By (200)
Published on May 1, 1992in The American Journal of Clinical Nutrition 6.55
C J Ley1
Estimated H-index: 1
B Lees1
Estimated H-index: 1
J C Stevenson1
Estimated H-index: 1
552 Citations Source Cite
Published on Jun 1, 1982in Clinical Chemistry 8.64
G R Warnick9
Estimated H-index: 9
(University of Washington),
J Benderson2
Estimated H-index: 2
(University of Washington),
John J. Albers83
Estimated H-index: 83
(University of Washington)
1,843 Citations
Published on Apr 1, 2000in The American Journal of Clinical Nutrition 6.55
Bret H. Goodpaster79
Estimated H-index: 79
(University of Pittsburgh),
F. L. Thaete4
Estimated H-index: 4
(University of Pittsburgh),
David E. Kelley76
Estimated H-index: 76
(University of Pittsburgh)
Background: Adipose tissue (AT) content of the thigh is generally not considered to be associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the thigh is a determinant of IR. Objective: We investigated whether subcompartments of AT within the thigh are determinants of IR. Design: Midthigh AT, muscle composition, and insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40 obese, glucose-tolerant (GT) and 15 lean, GT volu...
430 Citations Source Cite
Published on Jan 1, 1995in Annals of Medicine 3.01
Peter Arner91
Estimated H-index: 91
(Karolinska Institutet)
Hydrolysis of triglycerides to fatty acids and glycerol in fat cells (lipolysis) is of importance for the control of lipid and carbohydrate metabolism. This process is regulated by several hormones and parahormones acting on cyclic AMP formation or breakdown, which in turn influences the activity of hormone sensitive lipase. The latter enzyme stimulates hydrolysis of triglycerides in fat cells. It is well established through in vivo and in vitro investigations that there are regional variations ...
314 Citations Source Cite
Published on Jan 1, 1997in Hormone Research in Paediatrics 2.10
Philip J. Lee1
Estimated H-index: 1
Iain Cranston5
Estimated H-index: 5
(University of Cambridge)
+ 2 AuthorsAlbert Aynsley Green1
Estimated H-index: 1
We report the treatment of a 14-year-old Indian boy with acanthosis nigricans and hyperinsulinaemia with metformin in an attempt to improve his skin lesions. Oral metformin was used for 6 months with
13 Citations Source Cite
Published on Jul 1, 1995in Metabolism-clinical and Experimental 5.96
William T. Cefalu21
Estimated H-index: 21
(Wake Forest University),
Zhong Q. Wang5
Estimated H-index: 5
(Wake Forest University)
+ 5 AuthorsRandy L. Anderson6
Estimated H-index: 6
(Wake Forest University)
Abstract Recent studies have shown that central obesity (increased waist to hip ratio [WHR]) is related to insulin resistance and aging. Furthermore, in central-obesity states, the intraabdominal fat (IAF) depot has been postulated to contribute most to the development of insulin resistance. Therefore, the observed insulin resistance of aging may be related more to changes in body composition than to aging per se. The purpose of this study was to explore the association of IAF with age and insul...
168 Citations Source Cite
Published on May 1, 1990in Stroke 6.24
Aaron R. Folsom153
Estimated H-index: 153
(University of Minnesota),
Ronald J. Prineas46
Estimated H-index: 46
(University of Minnesota)
+ 1 AuthorsRonald G. Munger38
Estimated H-index: 38
(University of Minnesota)
The relation between body fat distribution, as measured by the waist-to-hip circumference ratio, and the 2-year incidences of hypertension and stroke were examined in a cohort of 41,837 women aged 55-69 years. Women who developed hypertension were 2.1 (95% confidence interval 1.7-2.6) times more likely to be in the upper tertile of waist-to-hip ratio than those who did not. Adjustment for age, body mass index (kilograms per meter squared), cigarette smoking, physical activity, alcohol intake, an...
203 Citations Source Cite
Published on Dec 2, 1998in JAMA 47.66
Kathryn M. Rexrode69
Estimated H-index: 69
Vincent J. Carey57
Estimated H-index: 57
+ 5 AuthorsJoAnn E. Manson229
Estimated H-index: 229
Context.—Obesity is a well-established risk factor for coronary heart disease (CHD), but whether regional fat distribution contributes independently to risk remains unclear.Objective.—To compare waist-hip ratio (WHR) and waist circumference in determining risk of CHD in women.Design and Setting.—Prospective cohort study among US female registered nurses participating in the Nurses' Health Study conducted between 1986, when the nurses completed a questionnaire, and follow-up in June 1994.Particip...
1,026 Citations Source Cite
Published on May 1, 1996in Diabetes 7.27
David G Carey5
Estimated H-index: 5
Arthur Jenkins36
Estimated H-index: 36
+ 2 AuthorsDonald J. Chisholm63
Estimated H-index: 63
Insulin resistance appears to be central to obesity, NIDDM, hyperlipidemia, and cardiovascular disease. While obese women with abdominal (android) fat distribution are more insulin resistant than those with peripheral (gynecoid) obesity, in nonobese women, the relationship between abdominal fat and insulin resistance is unknown. By measuring regional adiposity with dual-energy X-ray absorptiometry and insulin sensitivity by euglycemic-hyperinsulinemic clamp in 22 healthy women, with a mean ± SE ...
550 Citations Source Cite
Published on Aug 15, 2001in Journal of Applied Physics 2.18
Hussein H. Hamdeh21
Estimated H-index: 21
(Wichita State University),
X. Zhang2
Estimated H-index: 2
(Wichita State University)
+ 3 AuthorsY. S. Liou1
Estimated H-index: 1
(National Chung Cheng University)
Melt-spun ribbons of tetragonal Pr2Fe14B exhibit favorable hard magnet characteristics. Technically relevant materials based on this compound, however, generally contain a certain amount of soft magnetic α-Fe or Fe3−xBx for remanence enhancement through exchange coupling. The nominal off-stoichiometric compositions lead to metallurgical complications, which are not easily resolvable by standard phase identification techniques such as x-ray diffraction and thermal magnetic analysis. As a viable a...
26 Citations Source Cite
Cited By200
Published on Jan 1, 2009
Insulin resistance (IR) is well documented in type 1 diabetes (T1D) and is theorized to relate to diabetes complications, including renal and coronary artery disease (CAD). The hyperinsulinemic-euglycemic clamp technique provides accurate assessment of IR, yet the laborious, costly, and invasive nature of this technique is often inappropriate for large investigations. Increasing use of the Estimated Glucose Disposal (eGDR) equation in T1D makes further examination of this equation desirable as i...
Published on Dec 1, 2012in Journal of Arthroplasty 3.34
Jennifer E. Stevens-Lapsley22
Estimated H-index: 22
(University of Colorado Boulder),
Michael J. Bade8
Estimated H-index: 8
(University of Colorado Boulder)
+ 2 AuthorsMichael R. Dayton12
Estimated H-index: 12
(University of Colorado Boulder)
A prospective, randomized investigation compared early clinical outcomes of total knee arthroplasty (TKA) using conventional or minimally invasive surgical (MIS) approaches (n = 44). Outcome measures included isometric quadriceps and hamstrings strength, quadriceps activation, functional performance, knee pain, active knee range of motion, muscle mass, the Short Form-36, and Western Ontario and McMaster University Osteoarthritis Index, assessed preoperatively and 4 and 12 weeks after TKA. Four w...
24 Citations Source Cite
Published on Jan 1, 2009in Hormones, brain and behavior
Jill E. Schneider24
Estimated H-index: 24
(Lehigh University),
A.G. Watts1
Estimated H-index: 1
Gonadal hormones have profound effects on energy metabolism. Energy metabolism, in turn, controls the synthesis and secretion of the sex hormones. In addition to having reversible effects on energy metabolism in adults, sex hormones in utero set developmental events in motion that determine sexually dimorphic, lifelong patterns of body fat distribution. These patterns of body fat distribution are strongly associated with the prevalence of disease and mortality. To understand obesity-associated d...
6 Citations Source Cite
Published on Jan 1, 2008
Obesity is one of the major risk factors of atherosclerosis and arterial stiffness. Recent evidence suggests detrimental effect of fat mass rather than overall body mass. Abdominal fat has been indicated to have more negative impact than other fat depots. We evaluated the impact of regional fat distribution on atherosclerosis and compared the variances explained by 11-different adiposity measures on atherosclerosis and arterial stiffness among bi-racial women in menopausal transition. All analys...
Published on Jun 1, 2016in Pediatric Diabetes 3.17
H. Samouda5
Estimated H-index: 5
Carine De Beaufort20
Estimated H-index: 20
(Centre Hospitalier de Luxembourg)
+ 9 AuthorsMichel Vaillant21
Estimated H-index: 21
Background Childhood obesity is associated with early cardiometabolic risk (CMR), increased risk of adulthood obesity, and worse health outcomes. Leg fat mass (LFM) is protective beyond total fat mass (TFM) in adults. However, the limited evidence in children remains controversial. Objective We investigated the relationship between LFM and CMR factors in youth. Subjects A total of 203 overweight/obese children, 7–17-yr-old, followed in the Pediatric Clinic, Luxembourg. Methods TFM and LFM by dua...
5 Citations Source Cite
Published on Jan 1, 2015in Obesity 4.04
Daniel H. Bessesen14
Estimated H-index: 14
(Anschutz Medical Campus),
Kimberly Cox-York6
Estimated H-index: 6
(Colorado State University)
+ 4 AuthorsRachael E. Van Pelt20
Estimated H-index: 20
(Anschutz Medical Campus)
Objectives Postprandial lipemia worsens after menopause, but the mechanism remains unknown. The hypothesized menopause-related postprandial lipemia would be (1) associated with reduced storage of dietary fatty acids (FA) as triglyceride (TG) in subcutaneous adipose tissue (SAT) and (2) improved by short-term estradiol (E2). Methods Twenty-three pre- (mean ± SD: 42 ± 4 years) and 22 postmenopausal (55 ± 4 years) women with similar total adiposity were studied. A subset of postmenopausal women (n ...
9 Citations Source Cite
Published on Jan 1, 2011
Manisha Gupte1
Estimated H-index: 1
(Vanderbilt University)
Published on Aug 6, 2012
T. Barry Levine26
Estimated H-index: 26
Arlene B. Levine9
Estimated H-index: 9
1 Citations Source Cite
Published on Dec 1, 2005in BMC Cardiovascular Disorders 1.81
Henry S. Kahn40
Estimated H-index: 40
Background Body mass index (BMI, kg/m2) may not be the best marker for estimating the risk of obesity-related disease. Consistent with physiologic observations, an alternative index uses waist circumference (WC) and fasting triglycerides (TG) concentration to describe lipid overaccumulation.
185 Citations Source Cite
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