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Contributions of total and regional fat mass to risk for cardiovascular disease in older women.

Published on May 1, 2002in American Journal of Physiology-endocrinology and Metabolism 4.02
· DOI :10.1152/ajpendo.00467.2001
R. E. Van Pelt7
Estimated H-index: 7
(Anschutz Medical Campus),
Ellen M. Evans34
Estimated H-index: 34
+ 2 AuthorsWendy M. Kohrt60
Estimated H-index: 60
(Anschutz Medical Campus)
Abstract
The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1) area under the curve for the insulin (INSAUC) response to an oral glucose tolerance test (OGTT), 2) product of the OGTT glucose and insulin areas (INSAUC×GLUAUC), 3) serum triglycerides (TG), and 4) high-density lipoprotein (HDL)-cholesterol. Trunk fat mass was the strongest independent predictor of each of the primary dependent variables. In multivariate regression models, trunk fat mass was associated with unfavorable levels of INSAUC, INSAUC×GLUAUC, TG, and HDL-C, whereas leg fat mass was favorably associated with each of these variables. Thus trunk fat is a strong independent predictor of i...
  • References (38)
  • Citations (203)
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References38
Newest
Published on Aug 15, 2001in Journal of Applied Physics 2.18
Hussein H. Hamdeh22
Estimated H-index: 22
(Wichita State University),
X. Zhang1
Estimated H-index: 1
(Wichita State University)
+ 3 AuthorsY. S. Liou1
Estimated H-index: 1
(National Chung Cheng University)
Melt-spun ribbons of tetragonal Pr2Fe14B exhibit favorable hard magnet characteristics. Technically relevant materials based on this compound, however, generally contain a certain amount of soft magnetic α-Fe or Fe3−xBx for remanence enhancement through exchange coupling. The nominal off-stoichiometric compositions lead to metallurgical complications, which are not easily resolvable by standard phase identification techniques such as x-ray diffraction and thermal magnetic analysis. As a viable a...
25 Citations Source Cite
Published on Jun 1, 2001in Journal of Applied Physiology 3.26
Ellen M. Evans34
Estimated H-index: 34
,
Rachael E. Van Pelt21
Estimated H-index: 21
+ 3 AuthorsWendy M. Kohrt60
Estimated H-index: 60
The independent and combined effects of exercise training and hormone replacement therapy (HRT) on body composition, fat distribution, glucose tolerance, and insulin action were studied in postmenopausal women, aged 68 ± 5 yr, assigned to control (n = 19), exercise (n = 18), HRT (n = 15), and exercise + HRT (n = 16) groups. The exercise consisted of 2 mo of flexibility exercises followed by 9 mo of endurance exercise. HRT was conjugated estrogens 0.625 mg/day and trimonthly medroxyprogesterone a...
52 Citations Source Cite
Published on May 1, 2001in Annals of Internal Medicine 19.38
Ellen F. Binder33
Estimated H-index: 33
(Washington University in St. Louis),
Daniel B. Williams13
Estimated H-index: 13
(Washington University in St. Louis)
+ 2 AuthorsWendy M. Kohrt60
Estimated H-index: 60
(Washington University in St. Louis)
Background: Coronary heart disease (CHD) is the leading cause of death among older women. In observational studies, the incidence of CHD has been reduced in postmenopausal women who take hormone replacement therapy (HRT). A low serum level of high-density lipoprotein (HDL) cholesterol is one of the risk factors predictive of death from CHD. Objective: To determine the effects of HRT on serum lipid and lipoprotein levels in elderly women. Design: Randomized, double-blind, placebo-controlled trial...
50 Citations Source Cite
Published on Mar 1, 2001in Diabetes 7.27
Louis Pérusse77
Estimated H-index: 77
,
Treva Rice55
Estimated H-index: 55
+ 9 AuthorsMichael A. Province78
Estimated H-index: 78
To identify chromosomal regions harboring genes influencing the propensity to store fat in the abdominal area, a genome-wide scan for abdominal fat was performed in the Quebec Family Study. Cross-sectional areas of the amount of abdominal total fat (ATF) and abdominal visceral fat (AVF) were assessed from a computed tomography scan taken at L4-L5 in 521 adult subjects. Abdominal subcutaneous fat (ASF) was obtained by computing the difference between ATF and AVF. The abdominal fat phenotypes were...
142 Citations Source Cite
Frank Caserta1
Estimated H-index: 1
,
Tamara Tchkonia41
Estimated H-index: 41
+ 7 AuthorsJames L. Kirkland53
Estimated H-index: 53
Regional differences in free fatty acid (FFA) handling contribute to diseases associated with particular fat distributions. As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single perirenal than in epididymal cells matched for lipid content. Uptake by human omental preadipocytes was greater than uptake by abdominal subcutaneous preadipocytes. Adipose-specific fatty acid binding protein (aP2) and keratinocyte lipid binding protei...
65 Citations Source Cite
Published on Jun 1, 2000in Diabetes 7.27
Carl Montague17
Estimated H-index: 17
,
Stephen O’Rahilly115
Estimated H-index: 115
Although an individual's total fat mass predicts morbidities such as coronary artery disease and diabetes, the anatomical distribution of adipose tissue is a strong and independent predictor of such adverse health outcomes. Thus, obese individuals with most of their fat stored in visceral adipose depots generally suffer greater adverse metabolic consequences than similarly overweight subjects with fat stored predominantly in subcutaneous sites. A fuller understanding of the biology of central ob...
570 Citations Source Cite
Published on Jun 1, 2000in British Journal of Nutrition 3.66
Keith N. Frayn64
Estimated H-index: 64
The association between abdominal fat accumulation and risk of chronic diseases, including type II diabetes and coronary heart disease, has long been recognized. Insulin resistance may be a key factor in this link. Many studies have pointed to an association between insulin resistance and intra-abdominal fat accumulation (visceral obesity). However there is no clear proof of a causal link between visceral fat accumulation and insulin resistance. In assessing the probability of a causal link, it ...
325 Citations Source Cite
Published on Apr 1, 2000in The American Journal of Clinical Nutrition 6.55
Bret H. Goodpaster80
Estimated H-index: 80
(University of Pittsburgh),
F L Thaete6
Estimated H-index: 6
(University of Pittsburgh),
David E. Kelley79
Estimated H-index: 79
(University of Pittsburgh)
Background: Adipose tissue (AT) content of the thigh is generally not considered to be associated with insulin resistance (IR), but it is unclear whether the distribution of AT in the thigh is a determinant of IR. Objective: We investigated whether subcompartments of AT within the thigh are determinants of IR. Design: Midthigh AT, muscle composition, and insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40 obese, glucose-tolerant (GT) and 15 lean, GT volu...
436 Citations Source Cite
Published on Sep 1, 1999in Diabetes Care 13.40
Masafumi Matsuda20
Estimated H-index: 20
(University of Texas Health Science Center at San Antonio),
Ralph A. DeFronzo134
Estimated H-index: 134
OBJECTIVE: Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insulin clamp technique. In this study, we compare various insulin sensitivity indices derived from the OGTT with whole-body insulin sensitivity measured by the euglycemic insulin cla...
3,580 Citations Source Cite
Published on Feb 1, 1999in International Journal of Obesity 5.16
As Ryan1
Estimated H-index: 1
,
Bj Nicklas1
Estimated H-index: 1
Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors
133 Citations Source Cite
Cited By203
Newest
Published on Jan 23, 2019in Scientific Reports 4.12
Yu-Chung Tsao1
Estimated H-index: 1
(Memorial Hospital of South Bend),
Yi-Yen Lee10
Estimated H-index: 10
(National Yang-Ming University)
+ 4 AuthorsWen-Cheng Li7
Estimated H-index: 7
(Memorial Hospital of South Bend)
Lung function deterioration is frequently observed in overweight and obese patients. In the current study, we explored the contribution of body fat (BF) composition, particularly visceral and nonvisceral adiposity, to lung function deterioration. In addition, we examined gender- and age-specific differences in the association between the joint effects of BF% and C-reactive protein (CRP) concentrations with lung function. This cross-sectional study involved 17,802 subjects undergoing health check...
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Published on May 1, 2019in Diabetes-metabolism Research and Reviews 3.90
Chen-Jung Wu4
Estimated H-index: 4
(National Defense Medical Center),
Tung-Wei Kao9
Estimated H-index: 9
(National Taiwan University)
+ 2 AuthorsWei-Liang Chen9
Estimated H-index: 9
(National Defense Medical Center)
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Published on Dec 1, 2018in BMC Musculoskeletal Disorders 2.00
S. Ibeneme2
Estimated H-index: 2
(University of Nigeria, Nsukka),
C. Ekanem1
Estimated H-index: 1
(University of Nigeria, Nsukka)
+ 4 AuthorsO.E. Oboh1
Estimated H-index: 1
(University of Benin)
Background Depletion of ovarian hormone in postmenopausal women has been associated with changes in the locomotor apparatus that may compromise walking function including muscle atrophy/weakness, weight gain, and bone demineralization. Therefore, handgrip strength (HGS), bone mineral density (BMD) and body composition [percentage body fat mass (%BFM), fat mass (FM), Fat-free mass (FFM) and body mass index (BMI)], may significantly vary and predict WB in postmenopausal women. Consequently, the st...
1 Citations Source Cite
Published on Jul 8, 2018in Experimental Diabetes Research
Ming-Kuo Ting2
Estimated H-index: 2
(Memorial Hospital of South Bend),
Pei-Ju Liao (Oriental Institute of Technology)+ 4 AuthorsKuang-Hung Hsu32
Estimated H-index: 32
Background. An accurate and comprehensive anthropometric measure for predicting type 2 diabetes mellitus (T2DM) has not yet been depicted. Methods. A total of 8450 nondiabetic participants were recruited during 2000–2010 in Taiwan. The cohort was followed up to the end of 2013, over an average of 8.87 years. At recruitment, participants completed a questionnaire related to basic demographics, lifestyle variables, personal disease history, and family disease history. 3D body surface scanning was ...
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Published on May 1, 2018
Naima Covassin10
Estimated H-index: 10
(Mayo Clinic),
Fatima H. Sert-Kuniyoshi10
Estimated H-index: 10
(Mayo Clinic)
+ 5 AuthorsVirend K. Somers96
Estimated H-index: 96
(Mayo Clinic)
Abstract Objective To examine whether experimentally induced weight gain raises ambulatory blood pressure (BP) in healthy subjects and identify any relationship between changes in BP and changes in regional fat distribution. Patients and Methods Twenty-six normal weight subjects were randomized to 8 weeks of weight gain through overfeeding (n=16; age, 30.4±6.6 years) or to weight maintenance (controls; n=10; age, 27.1±7.7 years) between July 2004 and August 2010. Measures of body composition via...
2 Citations Source Cite
Published on Apr 1, 2018in International Journal of Obesity 5.16
Senthil K. Vasan12
Estimated H-index: 12
,
Clive Osmond114
Estimated H-index: 114
+ 5 AuthorsFredrik Karpe23
Estimated H-index: 23
Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease risk
7 Citations Source Cite
Published on Jan 1, 2018in International Journal of Endocrinology 2.34
Bin Wu5
Estimated H-index: 5
(Kunming Medical University),
Jingshan Huang8
Estimated H-index: 8
(University of South Alabama)
+ 3 AuthorsTsutomu Kazumi23
Estimated H-index: 23
(Mukogawa Women's University)
The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tole...
1 Citations Source Cite
Published on Dec 1, 2017in Cardiovascular Diabetology 5.24
Eugene Han7
Estimated H-index: 7
(Keimyung University),
Yong-ho Lee23
Estimated H-index: 23
(Yonsei University)
+ 3 AuthorsBong Soo Cha39
Estimated H-index: 39
(Yonsei University)
Background Although central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investigated.
5 Citations Source Cite
Published on Nov 1, 2017in BMJ Open 2.41
Yu-Chung Tsao , Jau-Yuan Chen3
Estimated H-index: 3
+ 2 AuthorsWen-Cheng Li7
Estimated H-index: 7
Objectives The global prevalence of hepatitis C virus (HCV) is approximately 2%–3%, and the prevalence of the positive anti-HCV antibody has been increasing. Several studies have evaluated regional adipose tissue distribution and metabolism over the past decades. However, no study has focused on the gender difference in visceral obesity among patients with HCV infection. Design Retrospective cross-sectional study. Setting We reviewed the medical records of patients who visited a hospital in Sout...
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