CRACM/Orai ion channel expression and function in human lung mast cells

Volume: 129, Issue: 6, Pages: 1628 - 1635.e2
Published: Jun 1, 2012
Abstract
Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the FcεRI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines. However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The recently discovered members of the CRACM/Orai ion channel family that carries the Ca(2+) release-activated Ca(2+) current are candidates.To investigate the...
Paper Details
Title
CRACM/Orai ion channel expression and function in human lung mast cells
Published Date
Jun 1, 2012
Volume
129
Issue
6
Pages
1628 - 1635.e2
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