Are peroxiredoxins tumor suppressors?
Abstract
It has been known for many years that free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), promote diseases such as cancer. Peroxiredoxins (Prdxs) are small H2O2 scavenging proteins that appear to have tumor preventive functions since loss of Prdx1 in mice leads to premature death from cancer. However, as Prdxs are antioxidants they also scavenge the H2O2 in cancer cells that way supporting survival and tumor...
Paper Details
Title
Are peroxiredoxins tumor suppressors?
Published Date
Aug 1, 2007
Volume
7
Issue
4
Pages
375 - 380
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