Prophylaxis against Group A Streptococci in Rheumatic Fever

THE prevention of recurrences of rheumatic fever depend on the protection of the patient against infection with Group A streptococci. The daily oral administration of sulfonamides or penicillin has been employed with considerable success for this purpose.1 The major limitation of continuous oral chemoprophylaxis is that patients are apt to forget to take their medication regularly. For this reason the administration of penicillin parenterally by...