p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

Cell64.50
Volume: 129, Issue: 3, Pages: 523 - 536
Published: May 4, 2007
Abstract
The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to the onset of senescence. While stratified epithelia such as skin, prostate, and breast are highly regenerative and account disproportionately for human cancers, genes essential for the proliferative capacity of their stem cells remain unknown. Here we analyze p63, a gene whose deletion in mice results in the catastrophic loss of all stratified...
Paper Details
Title
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
Published Date
May 4, 2007
Journal
Volume
129
Issue
3
Pages
523 - 536
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