Correlation of second virial coefficients and solubilities useful in protein crystal growth

The osmotic second virial coefficient, B, is a dilute solution parameter, so one may wonder what relationships exist among B and the many facets of protein crystal growth (PCG). In particular, knowledge of how a protein's solubility (S) depends on solution variables such as temperature, pH and ionic strength is very useful for finding optimum conditions for the PCG experiment. In this work, a correlation between the second virial coefficient and...