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Therapeutic strategies for patients with micropenis or penile dysmorphic disorder

Published on Sep 1, 2012in Nature Reviews Urology9.333
· DOI :10.1038/nrurol.2012.150
Oliver Kayes3
Estimated H-index: 3
(UCLH: University College Hospital),
Majid Shabbir4
Estimated H-index: 4
(UCLH: University College Hospital)
+ 1 AuthorsSuks Minhas21
Estimated H-index: 21
(UCLH: University College Hospital)
Abstract
In this Review, Kayes and colleagues discuss the aetiology, diagnosis and treatment options for congenital micropenis, acquired micropenis and penile dysmorphic disorder, including both nonsurgical and surgical techniques. They evaluate the role of phalloplasty and penile replacement surgery including transplantation, in this challenging clinical area.
  • References (97)
  • Citations (12)
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References97
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#1Derek J. Matoka (Children's Memorial Hospital)H-Index: 8
#2Earl Y. Cheng (Children's Memorial Hospital)H-Index: 20
Tissue engineering encompasses a multidisciplinary approach geared toward the development of biological substitutes designed to restore and maintain normal function in diseased or injured tissues. This article reviews the basic technology that is used to generate implantable tissue-engineered grafts in vitro that will exhibit characteristics in vivo consistent with the physiology and function of the equivalent healthy tissue. We also examine the current trends in tissue engineering designed to t...
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#1Geetu Pahlajani (Cleveland Clinic)H-Index: 8
#2Rupesh Raina (Case Western Reserve University)H-Index: 26
Last. Craig D. Zippe (Cleveland Clinic)H-Index: 48
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ABSTRACT Introduction Vacuum erection devices (VEDs) are becoming first‐line therapies for the treatment of erectile dysfunction and preservation (rehabilitation) of erectile function following treatment for prostate cancer. Currently, there is limited efficacy of the use of phosphodiesterase type 5 inhibitors in elderly patients, or patients with moderate to severe diabetes, hypertension, and coronary artery disease. Aim The article aims to study the role of VED in patients following prostate c...
33 CitationsSource
#1Shahid Khan (St. John's Hospital)H-Index: 3
#2Bhaskar K. Somani (St. John's Hospital)H-Index: 26
Last. Roland Donat (St. John's Hospital)H-Index: 7
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Study Type – Diagnostic (validating cohort) Level of Evidence 2a What’s known on the subject? and What does the study add? Reference ranges for normal penile length have been reported from several different countries and anthropometric differences have been noted between different nationalities and ethnic backgrounds. This study describes one of the largest cohorts of men undergoing penile size measurements in Europe and the largest UK study. The range of measurements collected in this study wil...
30 CitationsSource
ABSTRACT Introduction Controversy exists regarding the ideal candidates for penile rehabilitation after bilateral nerve‐sparing radical prostatectomy (BNSRP). Aim To test the effect of penile rehabilitation according to preoperative patient characteristics. Methods We included 435 consecutive patients treated with BNSRP between 2004 and 2008. Preoperative age, International Index of Erectile Function (IIEF) and Charlson Comorbidity Index (CCI) were used to subdivide patients into three groups ac...
31 CitationsSource
#1Kyung Kgi Park (University Health System)H-Index: 9
#2Seung Hwan Lee (University Health System)H-Index: 15
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ABSTRACT Introduction The adverse effects of long‐term drug therapy for prostate cancer (PCa) can dramatically impact patient quality of life and are considered to be important factors when selecting treatment. Aim To assess stretched penile length before and after long‐term androgen deprivation therapy (ADT) for treatment of PCa. Methods From January 2008 to June 2010 at a single institution, 39 consecutive patients without distant metastases who were elected to receive ADT as initial therapy f...
21 CitationsSource
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#2Nicola Mondaini (UniFI: University of Florence)H-Index: 29
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In Boston in 1954, Hartwell Harrison, the chief of urology at Harvard University, harvested a kidney and performed the first ever human organ transplantation [1]. The concept of cell transplantation developed after kidney transplantation and led to the first human bone marrow cell transplantation in the 1970s. At that time, researchers combined the scientific fields of device and material sciences with cell biology and in effect pioneered a new field called "tissue engineering" [2]. The first us...
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#1Hojjat Naderi (FUM: Ferdowsi University of Mashhad)H-Index: 1
#2Maryam Moghaddam Matin (FUM: Ferdowsi University of Mashhad)H-Index: 20
Last. Ahmad Reza Bahrami (FUM: Ferdowsi University of Mashhad)H-Index: 18
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Tissue engineering is a newly emerging biomedical technology, which aids and increases the repair and regeneration of deficient and injured tissues. It employs the principles from the fields of materials science, cell biology, transplantation, and engineering in an effort to treat or replace damaged tissues. Tissue engineering and development of complex tissues or organs, such as heart, muscle, kidney, liver, and lung, are still a distant milestone in twenty-first century. Generally, there are f...
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#1Laurence A. Levine (Rush University Medical Center)H-Index: 51
#2James Rybak (Rush University Medical Center)H-Index: 4
ABSTRACT Introduction Loss of penile length after penile prosthesis implantation is one of the most common complaints. There is no recognized reliable technique to gain length once the device is placed. Aims This noncontrolled pilot study was designed to evaluate the efficacy and safety of external penile traction therapy in men with a shortened penis used before inflatable prosthesis implantation. Methods Ten men with drug refractory erectile dysfunction and a complaint of a shorter penis as a ...
39 CitationsSource
#1Ozgu Aydogdu (Ankara University)H-Index: 12
#2Mehmet İlker Gökçe (Ankara University)H-Index: 9
Last. Önder Yaman (Ankara University)H-Index: 21
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Objective: To evaluate the change in penile size r bilateral nerve sparing retropubic radical prostatectomy (BNSRRP) and possible effect of Tadalafil. Materials and Methods: A total of 65 patients underwent BNSRRP and they were evaluated prospectively for a whole year of follow-up . The patients were randomized to control without rehabilitation (Group 1) or Tadalafil rehabilitation group (Group 2). The patients were evaluated at months 3, 6 and 12 postoperatively for erectile function, penile me...
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Penile wounds after traumatic and surgical amputation require reconstruction in the form of autologous tissue transfers. However, currently used techniques are associated with high infection rates, implant erosion and donor site morbidity. The use of tissue-engineered neocorpora provides an alternative treatment option. Contemporary tissue-engineering strategies enable the seeding of a biomaterial scaffold and subsequent implantation to construct a neocorpus. Tissue engineering of penile tissue ...
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Die Grose des Penis ist fur viele Manner ein Symbol der Mannlichkeit und der sexuellen Leistungsfahigkeit. Gleichzeitig sind viele Manner uberzeugt davon, dass ihr Selbstwertgefuhl und die Anerkennung in der Partnerschaft masgeblich durch die Penisgrose bestimmt sind und in der Regel „groser“ als besser empfunden wird. Aus diesem Grunde ist die Nachfrage nach asthetischen, den Penis vergrosernde Operationen rasant angestiegen. Inhalt dieses Kapitels ist es, zunachst eine Landmarke zu setzen mit ...
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#1Marco FalconeH-Index: 9
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Purpose of Review The aim of this manuscript is to systematically review the current literature on surgical management of the short penis, focusing on surgical and functional outcomes and postoperative complications.
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In cases of severe penile inadequacy, such as in pathological conditions involving penile amputation (e.g. penile cancer), or in 46,XY disorders of sex development with severe undervirilization or maldevelopment of the penis (e.g. idiopathic micropenis, cloacal exstrophy), standard (surgical) penile lengthening techniques do not provide patients with a phallus suitable for sexual intercourse. Genital dissatisfaction can lead to low self-esteem and psychosexual dysfunction. Therefore, phalloplast...
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