Mutational heterogeneity in cancer and the search for new cancer-associated genes
Abstract
Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with cancer genome studies: as the...
Paper Details
Title
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Published Date
Jun 16, 2013
Journal
Volume
499
Issue
7457
Pages
214 - 218
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