Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis
Abstract
Susceptibility to autoimmune hepatitis in white patients is associated with the human leukocyte antigen class II antigens DR3 and DR4. To analyze the molecular basis of these associations, we used oligonucleotide probes to determine the DRB, DQA and DQB hypervariable nucleotide sequences in 119 patients with autoimmune hepatitis and 177 matched controls. DRB3*0101, which encodes DR52a, predisposed patients most strongly to the disease. It was...
Paper Details
Title
Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis
Published Date
Mar 1, 1994
Journal
Volume
19
Issue
3
Pages
609 - 615
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