Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Nature64.80
Volume: 435, Issue: 7042, Pages: 646 - 651
Published: Jun 2, 2005
Abstract
Permanent modification of the human genome in vivo is impractical owing to the low frequency of homologous recombination in human cells, a fact that hampers biomedical research and progress towards safe and effective gene therapy. Here we report a general solution using two fundamental biological processes: DNA recognition by C2H2 zinc-finger proteins and homology-directed repair of DNA double-strand breaks. Zinc-finger proteins engineered to...
Paper Details
Title
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
Published Date
Jun 2, 2005
Journal
Volume
435
Issue
7042
Pages
646 - 651
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