Constitutive secretion of tau protein by an unconventional mechanism
Abstract
The microtubule-associated protein tau plays a critical role in the pathogenesis of Alzheimer's disease and several related disorders. In the disease tau aggregates into paired helical and straight filaments, which can form higher order neurofibrillary tangles in neurons and this pathology is associated with progressive neuronal loss and cognitive decline. Tau is a cytoplasmic protein and is thought to be released only from degenerating cells....
Paper Details
Title
Constitutive secretion of tau protein by an unconventional mechanism
Published Date
Dec 1, 2012
Journal
Volume
48
Issue
3
Pages
356 - 366
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Notes
History