Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Abstract
Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells. We identified 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide,...
Paper Details
Title
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Published Date
Mar 7, 2014
Journal
Volume
343
Issue
6175
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Notes
History