Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
Abstract
Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this distribution using Single Nucleotide Polymorphism (SNP) data from a population with non-stationary demographic history (such as that of modern humans). Application of our method to 47,576 coding SNPs found by direct resequencing...
Paper Details
Title
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
Published Date
May 30, 2008
Journal
Volume
4
Issue
5
Pages
e1000083 - e1000083
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History