Serrated Pathway to Colorectal Carcinogenesis: A Molecular Perspective

Serrated polyps of the colorectum are formed by a spectrum of lesions that share a unique histological feature- the presence of sawtooth-shaped crypts. In the last decade, significant advances have been made on deciphering the molecular differences between these morphologically similar lesions, which has paved path for our current understanding for their neoplastic potential. In particular, the sessile serrated adenoma has become to be...