Tissue inhibitor of metalloproteinases (TIMPs) in heart failure
Abstract
Remodeling of the myocardium and the extracellular matrix (ECM) occurs in heart failure irrespective of its initial cause. The ECM serves as a scaffold to provide structural support as well as housing a number of cytokines and growth factors. Hence, disruption of the ECM will result in structural instability as well as activation of a number of signaling pathways that could lead to fibrosis, hypertrophy, and apoptosis. The ECM is a dynamic...
Paper Details
Title
Tissue inhibitor of metalloproteinases (TIMPs) in heart failure
Published Date
Jun 30, 2011
Journal
Volume
17
Issue
4-5
Pages
693 - 706
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