A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Abstract
Cancer-associated cachexia (CAC) is a wasting syndrome characterized by systemic inflammation, body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited therapeutic options are available and the underlying mechanisms are poorly defined. Here we show that a phenotypic switch from WAT to brown fat, a phenomenon termed WAT browning, takes place in the initial stages of CAC, before skeletal muscle atrophy. WAT browning is...
Paper Details
Title
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Published Date
Sep 2, 2014
Journal
Volume
20
Issue
3
Pages
433 - 447
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