A transcription activator-like effector toolbox for genome engineering
Abstract
Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas sp. The DNA-binding domain of each TALE consists of tandem 34-amino acid repeat modules that can be rearranged according to a simple cipher to target new DNA sequences. Customized TALEs can be used for a wide variety of genome engineering applications, including transcriptional modulation and genome...
Paper Details
Title
A transcription activator-like effector toolbox for genome engineering
Published Date
Jan 1, 2012
Journal
Volume
7
Issue
1
Pages
171 - 192
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