Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers

Rationale The human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders. Objectives We examined the profile of the 5HT-2/α1/H1 antagonist ketanserin, the 5HT1a agonist buspirone and the beta adrenoceptor antagonist propranolol on pupillary and other measures of arousal. Materials and...