Canine Cutaneous Histiocytomas are Clonal Lesions as Defined by X-linked Clonality Testing
Abstract
Canine cutaneous histiocytoma (CCH) is the most common skin tumour of young dogs. CCH is assumed to be a tumour, but as these lesions often undergo complete regression, they have also been proposed to represent hamartomas or unregulated hyperplasia of polyclonal histiocytic cells. To demonstrate a monoclonal origin of CCH, and thereby a probable neoplastic nature, a clonality assay was established based on the heterozygosity of a polymorphic...
Paper Details
Title
Canine Cutaneous Histiocytomas are Clonal Lesions as Defined by X-linked Clonality Testing
Published Date
Aug 1, 2013
Volume
149
Issue
2-3
Pages
192 - 198
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