Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Abstract
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (IRS-1). Mice deficient in...
Paper Details
Title
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Published Date
Oct 15, 2004
Journal
Volume
306
Issue
5695
Pages
457 - 461
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