A Mechanism of Drug Action Revealed by Structural Studies of Enoyl Reductase
Abstract
Enoyl reductase (ENR), an enzyme involved in fatty acid biosynthesis, is the target for antibacterial diazaborines and the front-line antituberculosis drug isoniazid. Analysis of the structures of complexes of Escherichia coli ENR with nicotinamide adenine dinucleotide and either thienodiazaborine or benzodiazaborine revealed the formation of a covalent bond between the 2' hydroxyl of the nicotinamide ribose and a boron atom in the drugs to...
Paper Details
Title
A Mechanism of Drug Action Revealed by Structural Studies of Enoyl Reductase
Published Date
Dec 20, 1996
Journal
Volume
274
Issue
5295
Pages
2107 - 2110
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History