T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
Abstract
Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which the clinical recovery and effective anti-viral therapy is associated with the sustained viral control of effector T cells. In humans, chronic HBV infection often shows weak or absent virus-specific T-cell reactivity, which is described as the 'exhaustion' state characterized by poor effector cytotoxic activity, impaired cytokine production and sustained...
Paper Details
Title
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
Published Date
Mar 19, 2015
Journal
Volume
6
Issue
3
Pages
e1694 - e1694
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