Functional connectivity classification of autism identifies highly predictive brain features but falls short of biomarker standards

Autism spectrum disorders (ASD) are diagnosed based on early-manifesting clinical symptoms, including markedly impaired social communication. We assessed the viability of resting-state functional MRI (rs-fMRI) connectivity measures as diagnostic biomarkers for ASD and investigated which connectivity features are predictive of a diagnosis. Rs-fMRI scans from 59 high functioning males with ASD and 59 age- and IQ-matched typically developing (TD)...