Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene

One type of RNA editing involves the conversion of adenosine residues into inosine in double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR). A-to-I RNA editing of the coding sequence could result in synthesis of proteins not directly encoded in the genome. ADAR edits also non-coding sequences of target RNAs, such as introns and 3′-untranslated regions, which may affect splicing, translation, and mRNA stability....