Structure of the Mediator head module

The crystal structure of the Mediator head module from the fission yeast Schizosaccharomyces pombe is solved at 3.4 Å resolution. The Mediator complex has a central role in gene regulation, linking RNA polymerase II to its many transcriptional regulators. The structure of the budding yeast seven-subunit Mediator head module indicated three domains: the neck, fixed jaw and moveable jaw. Patrick Cramer and colleagues have determined the structure...