Localization of the K+–Cl− cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts

Na+-independent K+–Cl− cotransporters function in the regulation of cell volume, control of CNS excitability and epithelial ion transport. Several K+–Cl− cotransporter isoforms are expressed in the nervous system, and KCC3 in particular is expressed at significant levels in both the brain and spinal cord. The cellular localization of this transporter has, however, not been determined. In this study, we generated a polyclonal antibody against the...