Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.

Volume: 2, Issue: 3, Pages: 169 - 183
Published: Aug 31, 2005
Abstract
Camptothecin (CPT) and its analogs are some of the most potent antitumor agents known. However, their poor water-solubility and high toxicity require changes of their physicochemical and biological characteristics. Active lactone forms have provoked interest in the utility of CPT and its analogs again. Macromolecular chemical modifications and nanotechnological formulations have been used to obtain improved systems of CPT-related compounds. In...
Paper Details
Title
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy.
Published Date
Aug 31, 2005
Volume
2
Issue
3
Pages
169 - 183
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