Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis
Abstract
Excessive accumulation of smooth-muscle cells (SMCs) has a key role in the pathogenesis of vascular diseases. It has been assumed that SMCs derived from the outer medial layer migrate, proliferate and synthesize extracellular matrix components on the luminal side of the vessel. Although much effort has been devoted to targeting migration and proliferation of medial SMCs, there is no effective therapy that prevents occlusive vascular remodeling....
Paper Details
Title
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis
Published Date
Apr 1, 2002
Journal
Volume
8
Issue
4
Pages
403 - 409
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Notes
History