Exercise-Induced Improvement in Insulin Sensitivity Is Not Mediated by Change in Cardiorespiratory Fitness

Although exercise-induced improvement in cardiorespiratory fitness (CRF) and reduction in abdominal obesity are putative mechanisms by which chronic exercise attenuates insulin resistance (1), the independent contribution of each is unknown. We therefore investigated whether improvement in abdominal obesity and/or CRF mediates the effect of exercise on insulin sensitivity in abdominally obese adults. Participants included sedentary, abdominally...