Mechanical Stress-Induced Apoptosis of Endplate Chondrocytes in Organ-Cultured Mouse Intervertebral Discs : An Ex Vivo Study

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Volume: 28, Issue: 14, Pages: 1528 - 1533
Published: Jul 15, 2003
Abstract
Study design null Various amounts of static mechanical load were applied to mouse intervertebral discs in organ cultures. The apoptosis then was examined using nick end labeling. Two mitogen-activated protein kinase (MAPK) inhibitors were added to the medium. null Objectives null To establish an experimental model for detecting factors regulating chondrocyte apoptosis induced by mechanical stress, and to determine the role of MAPK and p38 in the...
Paper Details
Title
Mechanical Stress-Induced Apoptosis of Endplate Chondrocytes in Organ-Cultured Mouse Intervertebral Discs : An Ex Vivo Study
Published Date
Jul 15, 2003
Journal
Volume
28
Issue
14
Pages
1528 - 1533
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