Molecular mechanisms of insulin resistance and associated diseases
Abstract
Insulin resistance is a state in which higher than normal concentrations of insulin are required for normal response. The most common underlying cause is central obesity, although primary insulin resistance in normal-weight individuals is also possible. Excess abdominal adipose tissue has been shown to release increased amounts of free fatty acids which directly affect insulin signalling, diminish glucose uptake in muscle, drive exaggerated...
Paper Details
Title
Molecular mechanisms of insulin resistance and associated diseases
Published Date
Jan 1, 2007
Journal
Volume
375
Issue
1
Pages
20 - 35
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