High-glucose-cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL-22 expression: implications on impaired diabetic wound healing

Diabetes mellitus (DM) affects more than 170 million people worldwide with the number expected to increase 1. Impaired wound healing is a major complication associated with DM. Re-epithelialization following cutaneous injury involves keratinocyte migration and is essential for proper healing 2. Matrix metalloproteinases (MMPs) that degrade extracellular matrix proteins are critically involved in this process 3. Mononuclear cells have been...