Targeting the mitochondrial cell death pathway with gold compounds

There is much recent evidence showing that mitochondria play a critical role in the regulation of apoptosis (programmed cell death), making them an attractive target for the design of new anticancer drugs. A variety of different strategies targeting mitochondria for cancer therapy have been described in recent literature. Several different classes of gold-based compounds (in both Au(I) and Au(III) oxidation states) have attracted interest as...