Does DNA repair occur during somatic hypermutation?
Abstract
Activation-induced deaminase (AID) initiates a flood of DNA damage in the immunoglobulin loci, leading to abasic sites, single-strand breaks and mismatches. It is compelling that some proteins in the canonical base excision and mismatch repair pathways have been hijacked to increase mutagenesis during somatic hypermutation. Thus, the AID-induced mutagenic pathways involve a mix of DNA repair proteins and low fidelity DNA polymerases to create...
Paper Details
Title
Does DNA repair occur during somatic hypermutation?
Published Date
Aug 1, 2012
Journal
Volume
24
Issue
4
Pages
287 - 292
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