Formulation assessment of MK-886, a poorly water-soluble drug, in the beagle dog

MK-886 is an orally active leukotriene biosynthesis inhibitor which may have therapeutic benefits in inflammatory diseases. The compound is the sodium salt of an organic acid with low aqueous equilibrium solubility and potentially poor oral absorption characteristics. Since there is no adequate in vitro method of predicting oral bioavailability for such poorly water-soluble compounds, assessment of formulations was conducted in vivo. The beagle...