Balancing Proliferation with Igκ Recombination during B-lymphopoiesis
Abstract
The essential events of B-cell development are the stochastic and sequential rearrangement of immunoglobulin heavy (Igμ) and then light chain (Igκ followed by Igλ) loci. The counterpoint to recombination is proliferation, which both maintains populations of pro-B cells undergoing Igμ recombination and expands the pool of pre-B cells expressing the Igμ protein available for subsequent Igκ recombination. Proliferation and recombination must be...
Paper Details
Title
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis
Published Date
Apr 2, 2014
Journal
Volume
5
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