Unleashing the therapeutic potential of human kallikrein-related serine proteases

Published on Mar 1, 2015in Nature Reviews Drug Discovery57.618
· DOI :10.1038/nrd4534
Ioannis Prassas14
Estimated H-index: 14
Azza Eissa5
Estimated H-index: 5
+ 1 AuthorsEleftherios P. Diamandis99
Estimated H-index: 99
Members of the family of kallikrein (KLK)-related proteases are found in various tissues — including the airway, prostate and brain — and have a wide range of functions. The authors describe the roles of KLKs in health and disease, and highlight the small-molecule, peptide-based, protein-based, antibody-based and immunotherapeutic strategies that are being used to target KLKs in certain diseases.
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