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Control of colorectal cancer using organotin polymers

Published on Oct 2, 2014in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2014.966274
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(FAU: Florida Atlantic University)
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Abstract
The efforts described in this paper are aimed at designing organotin polymers that control the growth of various cancers; here colorectal cancer and to identify structure/property relationships that will assist in this goal. The growth of colorectal cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 value is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the nanograms/mL range are found. A number of products exhibit CI50 values greater than 2.
  • References (41)
  • Citations (0)
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References41
Newest
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(FAU: Florida Atlantic University)
The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependant on the nature of the Lewis base but the CI50 is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the picogra...
Published on Nov 1, 2014in Inorganica Chimica Acta 2.43
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Ngoc Trang Caroline Truong2
Estimated H-index: 2
(FAU: Florida Atlantic University)
+ 3 AuthorsNancy T. Trang5
Estimated H-index: 5
(UTA: University of Texas at Arlington)
Abstract Polyether esters are rapidly formed employing the interfacial condensation of organotin dihalides with glycyrrhetinic acid in high yield and oligomeric to polymeric chain length. Infrared spectroscopy shows the formation of tin–oxygen bonds. The products are a mixture of bridging and non-bridging structures about the tin atom. Proton NMR and MALDI MS results are consistent with the formation of the poly(ether esters). The dimethyltin, dibutyltin, and diphenyltin polymers exhibit good in...
Published in Journal of Organometallic Chemistry 2.07
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
Abstract Organotin polymers are easily synthesized employing interfacial polymerization systems involving the reaction of difunctional Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including the first water soluble organotin polymers. The organotin polymers exhibit a wide range of biological activities including the inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, pros...
Published on Jan 1, 2014in Journal of Polymer Materials 0.41
Charles E. Carraher24
Estimated H-index: 24
,
Michael R. Roner19
Estimated H-index: 19
+ 3 AuthorsTiasha Arnold1
Estimated H-index: 1
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(FAU: Florida Atlantic University)
+ 1 AuthorsMichael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
The effect of solvent on the ability to inhibit a group of cell lines was studied employing a series of water-soluble dibutyltin polyethers derived from various hydroxyl-terminated poly(ethylene glycols). Molecular weight as a function of time was essentially unchanged for a period of 30 weeks for the polyethers. Variations in test media can affect biological activities on the cell level as well as at the molecular level. The current study involves the evaluation of the cellular effects when dim...
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Marian Ayoub3
Estimated H-index: 3
(FAU: Florida Atlantic University)
+ 2 AuthorsNancy T. Trang5
Estimated H-index: 5
(UTA: University of Texas at Arlington)
In this study, organotin polyesters have been formed from the interfacial reaction between the disodium salt of chelidonic acid and a variety of organotin dihalides. Reactions occur rapidly within less than 15 seconds. Yields vary from moderate to high, and chain length varies from 30 to 800 repeat units. Infrared spectral analysis shows the presence of the Sn–O linkage and is consistent with the geometry about the tin being generally a mixture of tetrahedral or nonbridging and octahedral or bri...
Charles E. Carraher7
Estimated H-index: 7
(FAU: Florida Atlantic University),
Girish Barot11
Estimated H-index: 11
(BU: Boston University)
+ 2 AuthorsMichael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington)
The degradation of water soluble organotin polyether in the presence of trypsin was studied. The polymer was found to be stable to 4 days, the typical cancer cell line testing time. This is consistent with polymer activity against cancer cell lines being a result of the non-degraded chain and not controlled release of the organotin moiety. As a control trypsin activity was studied employing light scattering photometry and gel electrophoresis. The trypsin was active degrading bovine serine albumi...
Published on Jul 20, 2011in Journal of Molecular Signaling
Jyoti Nautiyal13
Estimated H-index: 13
(WSU: Wayne State University),
Shailender S. Kanwar9
Estimated H-index: 9
(WSU: Wayne State University)
+ 1 AuthorsAdhip P.N. Majumdar39
Estimated H-index: 39
(WSU: Wayne State University)
Metastatic colorectal cancer remains a serious health concern with poor patient survival. Although 5-Fluorouracil (5FU) or 5-FU plus oxaliplatin (FOLFOX) is the standard therapy for colorectal cancer, it has met with limited success. Recurrence of the tumor after chemotherapy could partly be explained by the enrichment of the chemo-resistant sub-population of cancer stem cells (CSCs) that possess the ability for self-renewal and differentiation into different lineages in the tumor. Therefore dev...
Published on Jul 1, 2011in CA: A Cancer Journal for Clinicians 223.68
Rebecca L. Siegel43
Estimated H-index: 43
(ACS: American Cancer Society),
Elizabeth Ward60
Estimated H-index: 60
(ACS: American Cancer Society)
+ 1 AuthorsAhmedin Jemal100
Estimated H-index: 100
(ACS: American Cancer Society)
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. A total of 1,596,670 new cancer cases an...
Cited By0
Newest
Michael R. Roner19
Estimated H-index: 19
(UTA: University of Texas at Arlington),
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 4 AuthorsJessica Frank1
Estimated H-index: 1
(FAU: Florida Atlantic University)
The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is the initial report of complete inhibition of the Zika virus by simple drugs. The ability to inhibit vaccinia virus is also reported. The inhibition of the vaccinia virus is shown by a number of organotin drugs including those also derived from lamivudine and camphoric a...