Control of colorectal cancer using organotin polymers

Published on Oct 2, 2014in Journal of the Chinese Advanced Materials Society
· DOI :10.1080/22243682.2014.966274
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Michael R. Roner19
Estimated H-index: 19
(University of Texas at Arlington)
+ 6 AuthorsMohammed H. Al-huniti4
Estimated H-index: 4
(Florida Atlantic University)
Abstract
The efforts described in this paper are aimed at designing organotin polymers that control the growth of various cancers; here colorectal cancer and to identify structure/property relationships that will assist in this goal. The growth of colorectal cancer is affected employing a wide range of organotin condensation polymers. The EC50 values are primarily dependent on the nature of the Lewis base but the CI50 value is dependent on both the nature of the Lewis base and Lewis acid. EC50 values down to the nanograms/mL range are found. A number of products exhibit CI50 values greater than 2.
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References41
Published on Feb 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
Poly[alkylene(arylene)oxystannanes] of the form below have been synthesized from dichlorostannanes and diols using a modified nonaqueous interfacial system consisting of acetonitrile and hydrocarbons. The products are preferentially capped with alcohol end-groups. Poly[alkylen(arylen)oxystannane] der folgenden Struktur wurden durch Grenzflachenpolykondensation von Dichlorstannen mit Diolen hergestellt. Dabei wurden modifizierte wasserfreie Losungsmittelsysteme aus Acetonitril und Kohlenwassersto...
25 Citations Source Cite
Published on Sep 5, 2003
Alaa S. Abd-El-Aziz22
Estimated H-index: 22
,
Charles E. Carraher23
Estimated H-index: 23
+ 2 AuthorsMartel Zeldin6
Estimated H-index: 6
128 Citations Source Cite
Published on Oct 18, 1972in Macromolecular Chemistry and Physics 2.49
Charles E. Carraher13
Estimated H-index: 13
(University of South Dakota),
Gary A. Scherubel3
Estimated H-index: 3
(University of South Dakota)
The synthesis of some poly(tin ethers) according to the following route is described The number average polymerization degrees range from 78 to 1400. Die Synthese einiger Poly-(zinnather) wird beschrieben, und zwar durch die in der Summary wiedergegebene Reaktion. Die mittleren Polymerisationsgrade liegen im Bereich von 78 bis 1400.
27 Citations Source Cite
Published on Jul 1, 2011in CA: A Cancer Journal for Clinicians 244.59
Rebecca L. Siegel43
Estimated H-index: 43
(American Cancer Society),
Elizabeth Ward74
Estimated H-index: 74
(American Cancer Society)
+ 1 AuthorsAhmedin Jemal96
Estimated H-index: 96
(American Cancer Society)
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. A total of 1,596,670 new cancer cases an...
3,124 Citations Source Cite
Published on Aug 15, 1999in Journal of Cell Science 4.40
E. Cohen1
Estimated H-index: 1
,
I. Ophir1
Estimated H-index: 1
,
Y.B. Shaul1
Estimated H-index: 1
The human colon adenocarcinoma cell line HT29 displays an undifferentiated phenotype under standard growth conditions. When these cells were cultured for 21 days and then treated with forskolin, most of the cells formed brush borders on their apical surfaces. Brush border formation was inhibited by cytochalasin D but not by colchicine. Colchicine, nocodazole and taxol were found to induce differentiation and apoptosis in HT29 cells. Differentiation was characterized by flattening of the cells, f...
59 Citations
Elvire Fournier4
Estimated H-index: 4
(French Institute of Health and Medical Research),
Catherine Passirani37
Estimated H-index: 37
(French Institute of Health and Medical Research)
+ 3 AuthorsJean-Pierre Benoit66
Estimated H-index: 66
(French Institute of Health and Medical Research)
Abstract In order to treat malignant brain tumors by local delivery of antineoplastic agents, the feasibility of 5-fluorouracil (5-FU)-sustained release biodegradable microspheres with a novel material, poly(methylidene malonate 2.1.2), was investigated using an emulsion/extraction method. This polymer was expected to present a slow degradation rate, thus leading to a long term local delivery system. Microparticles were successfully obtained and characterized in terms of drug loading, size, morp...
53 Citations Source Cite
Published on Jul 20, 2011in Journal of Molecular Signaling
Jyoti Nautiyal13
Estimated H-index: 13
(Wayne State University),
Shailender S. Kanwar9
Estimated H-index: 9
(Wayne State University)
+ 1 AuthorsAdhip P.N. Majumdar39
Estimated H-index: 39
(Wayne State University)
Metastatic colorectal cancer remains a serious health concern with poor patient survival. Although 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) is the standard therapy for colorectal cancer, it has met with limited success. Recurrence of the tumor after chemotherapy could partly be explained by the enrichment of the chemo-resistant sub-population of cancer stem cells (CSCs) that possess the ability for self-renewal and differentiation into different lineages in the tumor. Therefore de...
69 Citations Source Cite
Published on Jan 1, 2011in Digestive Diseases
Alastair J.M. Watson33
Estimated H-index: 33
(University of East Anglia),
Paul Collins Mbbs Mrcp7
Estimated H-index: 7
(University of Liverpool)
Colorectal cancer arises in individuals with acquired or inherited genetic predisposition who are exposed to a range of risk factors. Many of these risk factors are associated with affluent Western so
138 Citations Source Cite
Published on Mar 1, 2011in Advanced Drug Delivery Reviews 13.66
Jun Fang24
Estimated H-index: 24
(Sojo University),
Hideaki Nakamura13
Estimated H-index: 13
(Sojo University),
Hiroshi Maeda20
Estimated H-index: 20
(Sojo University)
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues. For example, angiogenesis leads to high vascular density in solid tumors, large gaps exist between endothelial cells in tumor blood vessels, and tumor tissues show selective extravasation and retention of macromolecular drugs. This EPR effect served as a basis for development of macromolecular anticancer therapy. We demons...
1,508 Citations Source Cite
Published on Nov 1, 2014in Inorganica Chimica Acta 2.26
Charles E. Carraher7
Estimated H-index: 7
(Florida Atlantic University),
Ngoc Trang Caroline Truong2
Estimated H-index: 2
(Florida Atlantic University)
+ 3 AuthorsNancy T. Trang5
Estimated H-index: 5
(University of Texas at Arlington)
Abstract Polyether esters are rapidly formed employing the interfacial condensation of organotin dihalides with glycyrrhetinic acid in high yield and oligomeric to polymeric chain length. Infrared spectroscopy shows the formation of tin–oxygen bonds. The products are a mixture of bridging and non-bridging structures about the tin atom. Proton NMR and MALDI MS results are consistent with the formation of the poly(ether esters). The dimethyltin, dibutyltin, and diphenyltin polymers exhibit good in...
7 Citations Source Cite
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