Alterations in Hepatic Mitochondrial Compartment in a Model of Obesity and Insulin Resistance

The objective of this paper is to evaluate adaptations in hepatic mitochondrial protein mass, function and efficiency in a rat model of high‐fat diet‐induced obesity and insulin resistance that displays several correlates to human obesity. Adult male rats were fed a high‐fat diet for 7 weeks. Mitochondrial state 3 and state 4 respiratory capacities were measured in liver homogenate and isolated mitochondria by using nicotinamide adenine...